Eradication of HIV-1: Is a Cure Possible?
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Stephen Dewhurst, PhD
Chair and Professor of Microbiology and Immunology
University of Rochester School of Medicine and Dentistry
Presentation Date: 5/25/2012
Release Date: 6/21/2012
- Describe the cellular and anatomic reservoirs of HIV-1 infection.
- Explain the medical interventions that led to Timothy Ray Brown being apparently cured of HIV-1 infection.
- Outline approaches that are being used to reactivate latent HIV-1 infection, in order to purge the virus.
- Explain how genetic engineering and zinc finger nucleases are being used to try to develop a cure.
Dr. Dewhurst is Dean's Professor and Chair of Microbiology & Immunology at the University of Rochester School of Medicine and Dentistry (URSMD). He received his Ph.D. from the University of Nebraska Medical Center in 1987, and performed postdoctoral training at Columbia University and at the Harvard School of Public Health, under the direction of Dr. Jim Mullins. His doctoral and postdoctoral work focussed on the pathogenesis of human and simian immunodeficiency viruses. He has been a member of the faculty at the University of Rochester since 1990, and served as Senior Associate Dean for Basic Research at the URSMD from 2007 to 2009. He has over 20 years experience as a molecular virologist, working on both RNA and DNA viruses (including HIV-1 and human herpesviruses) and is expert in the areas of viral gene transfer vectors, HIV-1 vaccine development and neuroAIDS. He has served on many NIH special emphasis and regular grant review panels and is a former Study Section Chair as well as a past (2004-2008) member of the NIH Recombinant Advisory Committee (RAC), which oversees all recombinant DNA studies in human subjects. He serves as Director of the UR's NIH-funded Development Center for AIDS Research, and also directs a NIH-funded Predoctoral training program in HIV-1 research, in addition to his own research.